Without any attempt to investigate their chemical nature, their mechanism of action, nor the ways where each was related to the other, quinine compounds were accepted as default therapy for malaria about a century ago.

A. nor the ways where each was related to the other
B. nor how each was related to some other
C. or the way where one is related to the next
D. or the ways in which they are related to one another
E. or the ways that each related to some other

OA: D

What's wrong with options B and C?