With exponents, remember that you flip the fraction in the base to eliminate the negative in the exponent.

I think the best strategy would be to quickly eliminate all the negatives from the exponents by flipping the fractions. This will make it visually easier.

2 other things to remember are that when the negative is outside of the (), then that term MUST be negative, since 2 to any power must be positive. If the - is inside the (), then depending on the odd/even designation of the exponent, the sign will alternate.