Mice treated with certain statins intended to decrease blood pressure also experienced drug-induced toxic myopathy, also known as muscular degeneration. Scientists hypothesize that this may have occurred because the statins cause an over-activation of creatine kinases, which are known to cause muscular degeneration.

Which of the following experiments would yield the most useful results for analyzing the scientists’ hypothesis?


A. Administering statins to mice with increased creatine kinase activity and observing creatine kinase activity.

B. Injecting mice with a creatine kinase inhibitor before administering the statins and then monitoring muscle tissue response.

C. Injecting mice with creatine kinase inhibitors and then monitoring muscle tissue response.

D. Injecting mice with muscle repair medication and then monitoring levels of muscular response.

E. Measuring mice’s level of muscular myopathy, administering a creatine kinase inhibitor, and then measuring myopathy once more


OA B

Source: Veritas Prep