In the late 1980s the frog Epipedobates tricolor was found to produce a previously unknown compound that is 200 times a more effective painkiller as morphine is.

A) that is 200 times a more effective painkiller as
B) that has 200 times more effectiveness as a painkiller than
C) with 200 times more effectiveness as a painkiller than
D) that is 200 times more effective as a painkiller as
E) that is 200 times more effective as a painkiller than

OA:E

Source :GMATPrep EP2

Please explain POE