Hi VJesus12,
This question can be solved with a bit of general graphing (you do not need to be hyper-accurate with your drawing to get the correct answer).
To start, we're told that in the coordinate geometry plane, Point A is the midpoint between points (5,8) and (-3, -2). Draw those two points on a graph and draw a line connecting them. Since (5,8) is so much 'further in' to Quadrant 1 than (-3,-2) is into Quadrant 3, the midpoint (Point A) will clearly be in Quadrant 1.
Next, graph the point (4, -1). Draw a line from Point A to this new point. This point is "down and to the right" from Point A.... and since this new point is the midpoint between Point A and Point B, we know that extending that line further "down and to the right" would lead us to Point B. Thus, Point B would clearly be in Quadrant 4.
Final Answer: D
GMAT assassins aren't born, they're made,
Rich