In virtually all types of tissue in every animal species, dioxin induces the production of enzymes that are the organism's trying to metabolize, or render harmless. the chemical that is irritating it.

(A) trying to metabolize, or render harmless, the chemical that is irritating it

(E) attempt to metabolize, or render harmless, the chemical irritant

Correct answer is E. I am concerned if there is meaning change in following sentence.

Correct answer:In virtually all types of tissue in every animal species, dioxin induces the production of enzymes that are the organism's attempt to metabolize, or render harmless, the chemical irritant

1. Removing First Comma: In virtually all types of tissue in every animal species, dioxin induces the production of enzymes that are the organism's attempt to metabolize or render harmless, the chemical irritant - I think this does NOT make any sense

2. Removing First and Second Comma: In virtually all types of tissue in every animal species, dioxin induces the production of enzymes that are the organism's attempt to metabolize or render harmless the chemical irritant - I think this makes same sense as that of original sentence.