I'm always really cautious with DS problems that don't specify a limitation on a value. When we aren't told "x is a positive integer" or "y is a non-zero integer," that means we need to think about positive and negative integers, positive and negative fractions, and, of course, zero.
Statement 1: x < 0. From this we instantly know that x^3 is negative and 3^x is a fraction. And if x is an integer, then S < 0. But since the questions doesn't restrict us to think about specific numbers only, we can't solve with this statement alone, because what if x itself is a fraction? For instance, (-.5)^3 + 3^-.5 = -.125 + 1.72 = .47, which means S > 0.
Statement 2: |x| > 1. This is also insufficient. It tells us that the absolute value of x is greater than 1, but we don't know if it's positive or negative.
Combined: We still cannot answer because we still cannot determine whether whether x is an integer. If x = 2, then S = -2^3 + 3^-2 = -8 + 1/9 = -7 7/9. But if x = 1.5, then 1.5^3 + 3^-3/2 = -3.375 + SQRT27, which is greater than 0.