At least two means visiting 2 or 3 or 4 cities. The order matters, because going to New York then Los Angeles, for example, is a different itinerary than going to Los Angeles then New York. Since order matters, use permutations.
Visiting 2 cities out of 4, when order matters, is 4P2.
Visiting 3 out of 4, order matters, is 4P3.
Visiting 4 out of 4, order matters, is 4P4.
Add them together to get the total number of itineraries: 4P2 + 4P3 + 4P4.
This is a simple problem. The solution is the definition of permutations.
Permutation and Combination Problem
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