Unlike the body's inflammatory response to cuts and sprains, with widespread swelling and stiffness immobilizing the injured area until it heals, the body's response to sunburn is more localized and resulting in a distinct line dividing affected and unaffected areas of the skin.

A. with widespread swelling and stiffness immobilizing the injured area until it heals, the body's response to sunburn is more localized and resulting

B. where the injured area is immobilized with widespread swelling and stiffness until it has healed, sunburn generates a more localized response in the body, which results instead

C. with the injured area immobilized by means of widespread swelling and stiffness until healing, sunburn generates a more localized response in the body, one resulting

D. in which widespread swelling and stiffness immobilize the injured area until it has healed, the body's more localized response to sunburn results

E. in which widespread swelling and stiffness immobilize the injured area until healing, instead, the body's more localized response to sunburn results

OA D

I have a question. Is option with comma+with (,with) is correct? When it is correct?