Sentence Correction

Dear Friends,

I was having problems in answering the following question.

In human hearing, subtle differences in how the two ears hear a given sound help the listener determine the qualities of that sound.

(A) in how the two ears hear a given sound help the listener determine
(B) in the two ears hearing a given sound help the listener in determining
(C) in how a sound is heard by the two ears helps the listener determine
(D) between how the two ears hear a given sound helps the listener in determining
(E) between how a sound is heard by the two ears help the listener in determining


Please help.

OA after some discussions.

Regards
Deano.