Each handshake = one PAIR of men.
No handshake -- and thus no PAIR -- may be composed of two men from the SAME GROUP.
Thus, the question above can be rephrased as follows:
There are 6 groups in a room. Each group consists of 3 men. How many PAIRS of men can be formed if no pair may consist of two men from the same group?
Good pairs = total possible pairs - bad pairs.
Total possible pairs:
Number of pairs that can be formed from 18 men = 18C2 = (18*17)/(2*1) = 153.
Bad pairs:
A bad pair consists of two men from the SAME GROUP.
Number of pairs that be formed from each group of 3 men = 3C2 = (3*2)/(2*1) = 3.
Number of groups = 6.
To combine these options, we multiply:
3*6 = 18.
Thus:
Good pairs = 153-18 = 135.
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