Good = Total - Bad

The Total number of ways 6 people can be arranged is 6! or 720.

The Bad is the times where A & B are next to each other. Imagine A & B are stuck together and you have 5 people. A&B, C, D, E, and F. This group can be arranged 5! or 120 ways. This will count all the times A&B are sitting next to each other with A on one side of B. But A can also sit on the other side of B (picture the first count as the times A is to the left of B). To find the total number of ways A & B can sit next to each other, just multiply by 2 to get 240.

Now you can find the number of times A & B do not sit next to each other:

Good = Total - Bad
Good = 720 - 240
Good = 480

Whenever a question involves two things together or not together, treat them as a unit (as in the above solution.)

I think the below method is quicker.

_C_D_E_F_

we can arrange CDEF in 4!= 24 ways
for the gaps we have 5p2 ways =20 ways. [we can have A or B in any of the gaps].
Total =24*20=480 ways.