Toxoplasma Gondii

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Toxoplasma Gondii

by RumpelThickSkin » Mon Jun 14, 2010 12:04 am
Passage


The single-celled parasite known as Toxoplasma gondii infects more than half of the world's human population without creating any noticeable symptoms. Once inside the human body, Toxoplasma rapidly spreads to the heart and other organs. It can even penetrate the tight barrier that normally protects the brain from most pathogens. Yet, the blood of infected persons carries very few free-floating Toxoplasma cells. Scientists have long been puzzled by this ability of Toxoplasma to parasitize the human body without triggering an immune response and without an appreciable presence in the bloodstream. Recent research, however, has shed light on the ways in which Toxoplasma achieves its remarkable infiltration of the human body.

Though there are few individual Toxoplasma cells coursing freely in the blood of an infected person, scientists have discovered that the parasite is quite common in certain cells, known as dendritic cells, involved in the human immune system. Dendritic cells are found in the digestive tract and frequently come into contact with the various pathogens that enter the human body through food and water. When the dendritic cells encounter pathogens, they travel to lymph nodes and relay this information to other immune cells that then take action against the reported pathogen. Scientists have found, however, that Toxoplasma is capable of hijacking dendritic cells, forcing them from their usual activity and using them as a form of transportation to infect the human body quickly. Without this transport mechanism, Toxoplasma could not reach the better-protected areas of the body.

Toxoplasma invades the human body through consumption of the undercooked meat of infected animals, primarily pigs and chickens. Other animals, such as cats, can become infected as well. In fact, cats are a necessary component in the reproductive cycle of Toxoplasma, since the animal's intestines are the parasite's sole breeding ground. Toxoplasma creates egg-like cysts, known as oocysts, in the cats' intestines. These oocysts are shed in the cats' droppings and contaminate ground water and soil, eventually finding their way into the food chain. Because Toxoplasma must somehow find its way into a new host cat in order to reproduce, it cannot kill its current host. Instead, it waits for the host, usually a small rodent, to be eaten by a cat, thus providing Toxoplasma the opportunity to reproduce.

Question : It can be inferred from the passage that which of the following statements is true of dendritic cells in the human body?

A . They are produced by the lymphatic system.

B. They are more numerous in the digestive tract than in any other part of the body.

C. Most dendritic cells of persons infected with Toxoplasma carry the parasite.

D. They are the only cells capable of being infected by Toxoplasma.

E. They are able to penetrate the membranes surrounding the brain.

[spoiler] B & E both seem right to me. Why is B incorrect rather what is the POE for B? OA is E [/spoiler]

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by albatross86 » Mon Jun 14, 2010 2:35 am
A. We only know that they travel to the lymph nodes, not that they are produced there.

B. Dendritic cells are found in the digestive tract. Does that mean they are not found anywhere else, or found more frequently here? I could say for example, I have hair on my arms. Does that mean I have more hair on my arms than anywhere else in the body, or that I don't have hair on my head? No. This cannot be inferred.

C. We only know that the parasite is "quite common in dendritic cells" and cannot infer this.

D. They dendritic cells are unique because they are the sole form of transportation for the parasite, but this does not mean other cells could not be infected.

E. The first para tells us that the parasite can penetrate the barrier. And the second para tells us that hijacked dendritic cells are the parasites' sole mode of transportation in the body. Thus it can be inferred that dendritic cells can penetrate the barrier.